In general, the recurrent genomic and transcriptional characteristics of 51 breast cancer cell lines mirror those of 145 primary breast tumors, although some significant differences are documented. The cell lines that comprise the system also exhibit the substantial genomic, transcriptional, and biological heterogeneity found in primary tumors.Cited by: 2782. Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. This is a list of major breast cancer cell lines that are primarily used in breast cancer research.
The CCLE (Cancer Cell Line Encyclopedia) project is a collaboration between the Broad Institute, and the Novartis Institutes for Biomedical Research and its Genomics Institute of the Novartis Research Foundation to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer models, to develop integrated computational analyses that link distinct pharmacologic vulnerabilities to genomic patterns and to translate cell line integrative genomics into cancer. On the other hand, the number of cell lines widely used for breast cancer studies is extremely small, with cell lines such as MCF7, T47D and MDAMB231 accounting for more than two-thirds of cell lines used in the associated studies. This raises the issue on how representative these few cell lines are of the vast diverse spectrum of breast tumors with distinct clinical implications.Cited by: 68.
A comprehensive set of breast cancer cell lines derived from ATCC master seed stocks to eliminate variability. Each panel features a compact disc containing signed certificates of analysis and product sheets for each individual cell line. The Breast Cancer p53 Hotspot Mutation Cell Panel (ATCC® No TCP-2010™) is comprised of eight select cell lines. This cell line panel is designed to help investigators unravel the relationship between TP53 (p53) gene mutations and oncogenesis.
74 rows · Cell lines database. p53 database. p53 mutations in cell lines. The hanbook of p53 . May 15, 2019 · Surprisingly, MDA-MB-231, a cancer cell line used in nearly all metastatic breast cancer research, showed little genomic similarities to patient tumor samples.Author: Jeffrey S. Buguliskis, Ph.D.
A immortal human cell line cell that has the characteristics: Human cell line derived from metastasis of cancer occurred in oral cavity, the same patient as T3M-1 Clone2 and T3M-1 Cl-10. CL11 Human lung adenocarcinoma cell line. Cell Lines Project v89, released 15-MAY-19. COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer.