HBB hemoglobin subunit beta - Gene - GTR - NCBI - hbb sequence normal adult hemoglobin

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hbb sequence normal adult hemoglobin - Introduction - Human Hemoglobin (HbA) and the HBB gene


Jul 08, 2018 · HBB hemoglobin subunit beta [ (human)] Gene ID: 3043, updated on 8-Jul-2018. The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. It is 146 amino acids long and has a molecular weight of 15,867 Da. Normal adult human HbA is a heterotetramer consisting of two alpha chains and two beta chains. HBB is encoded by the HBB gene on human chromosome 11.Aliases: HBB, CD113t-C, beta-globin, hemoglobin .

In adults, hemoglobin normally consists of four protein subunits: two subunits of beta-globin and two subunits of another protein called alpha-globin, which is produced from another gene called HBA. Each of these protein subunits is attached (bound) to an iron-containing molecule called heme; each heme contains an iron molecule in its center that can bind to one oxygen molecule. The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia.

HBB Gene Expression. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. These large family of proteins related to hemoglobin’s are encoded at five different chromosomal locations in humans. For example the α-like globin gene is expressed at chromosomal location 16p13.3. The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of .

HBB, CD113t-C, Hemoglobin beta, Hemoglobin beta chain, Hemoglobin subunit beta, Beta globin chain, Beta-globin, Hemoglobin, beta Target Sequences: NM_000518 NP_000509.1 P68871. Genetic variations in HBB are involved in resistance to malaria [MIM i:611162]. Hemoglobin S (Hb S), which at homozygosity is responsible for sickle cell anemia, is not associated with any clinical abnormality when heterozygous. At heterozygosity, Hb S confers an increase in protection from life-threatening malaria.

Species: Human HBB (3043), Mouse Hbb (15127), Rat Hbb (24440), cow HBB (280813), domestic cat Human (3043) Summary: The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. About the HBB gene. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G.